Perbedaan Kadar Endothelial Nitric Oxide Synthase pada Pasien STEMI dengan Komorbid Diabetes Melitus dan Tidak Komorbid Diabetes Melitus di RSUP Dr. M. Djamil Padang

Muhammad, bhagus Andina Putra (2023) Perbedaan Kadar Endothelial Nitric Oxide Synthase pada Pasien STEMI dengan Komorbid Diabetes Melitus dan Tidak Komorbid Diabetes Melitus di RSUP Dr. M. Djamil Padang. Diploma thesis, Universitas Andalas.

[img] Text (Cover abstrak)
Cover Abstract.pdf - Published Version

Download (683kB)
[img] Text (BAB 1)
BAB 1 .pdf - Published Version

Download (261kB)
[img] Text (Bab Penutup)
PENUTUP.pdf - Published Version

Download (278kB)
[img] Text (Daftar Pustaka)
Daftar Pustaka.pdf - Published Version

Download (216kB)
[img] Text
FULLTEXT 1.pdf - Published Version
Restricted to Repository staff only

Download (7MB) | Request a copy

Abstract

Cardiovascular disease is a leading cause of global mortality, with Indonesia ranking third in the highest cardiovascular deaths. Acute myocardial infarction, divided into STEMI and NSTEMI, is part of the acute coronary syndrome due to total occlusion of coronary arteries requiring immediate revascularization. Diabetes Mellitus reduces endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production, leading to endothelial dysfunction and an increased risk of vascular disease. DM-related endothelial dysfunction affects vascular relaxation and the formation of atherosclerotic plaques as well as thrombi in ST-elevation myocardial infarction (STEMI). The study's focus was on determining eNOS level differences in STEMI patients with and without comorbid diabetes mellitus at RSUP. Dr. M. djamil Padang. This research was an analytical observational study with a cross-sectional approach, using normality tests and the Mann-Whitney U Test. The research sample was collected using consecutive sampling techniques and obtained from the medical records of 72 confirmed STEMI patients, with and without comorbid DM. The research results indicated that the majority of patients were in the age range of 60-69 years (52.7%), male (86.1%), with a Body Mass Index (BMI) of 23-24.9 (45.8%), comorbid hypertension (52.7%), and a history of smoking (72.3%). The mean eNOS level in the control group was Median eNOS 38,839 U/mL with maximum level 584,762 U/ml and minimum 17,024 U/ml. Median eNOS level in the test group was 36,077 U/mL with the maximum level 679,754 U/ml and minimum 1,836 U/ml. There was no significant difference in eNOS levels between the two groups (Sig (2-Tailed) > 0.05).

Item Type: Thesis (Diploma)
Primary Supervisor: Dr. dr. Eka Fithra Elfi, Sp.JP(K)-FIHA
Uncontrolled Keywords: STEMI, eNOS, Endothelial Dysfunction, Diabetes Mellitus
Subjects: R Medicine > RC Internal medicine
R Medicine > RZ Other systems of medicine
Divisions: Fakultas Kedokteran > Profesi Dokter
Depositing User: S1 Pendidikan Kedokteran
Date Deposited: 13 Feb 2024 03:15
Last Modified: 13 Feb 2024 03:15
URI: http://scholar.unand.ac.id/id/eprint/461935

Actions (login required)

View Item View Item