HUBUNGAN RESISTENSI INSULIN DENGAN GAMBARAN KLINIS PADA SINDROM OVARIUM POLIKISTIK

MELIZA, WAHYUNI (2013) HUBUNGAN RESISTENSI INSULIN DENGAN GAMBARAN KLINIS PADA SINDROM OVARIUM POLIKISTIK. Diploma thesis, Universitas Andalas.

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Abstract

Polycystic ovary syndrome is an endocrine and metabolic disorders that is common in reproductive-aged women. PCOS is a group of symptoms, such as amenorrhea, oligomenorrhea, infertility, obesity, hirsustism, acne, alopecia, and achanthosis nigricans. Insulin resistance is believed to be one of the most common causes of PCOS through a various mechanisms, such as decreasing of IGFBP-I, increasing of IGF-I, activating of the serine autophsophorylation, increasing of the activation of P450c17, and decreasing of SHBG. These mechanisms can stimulate clinical manifestation of PCOS. This research aims to find out the relationship between insulin resistance and clinical manifestation of polycystic ovary syndrome. This research was done in patients with PCOS using cross sectional study with retrospective approach. Data was collected from 2009 -2011, with the sample of 105 patients. This research used Statistical analysis, that was chi square test. From this research found that 33,3% patients of PCOS have insulin resistance. Based on clinical manifestation found that 35,23% amenorrhea, 64,77% oligomenorrhea, 72,04% infertility, 50,5% obesity, 0,95% hirsustism, 20% acne, 0% alopecia and achanthosis nigricans. From 33,3% PCOS with insulin resistance, 40% amenorrhea, 60% oligomenorrhea, 71,9% infertility, 77,14% obesity, and 0% hirsustism. The results showed that there is a significant relationship between insulin resistance and obesity (p<0,05) and no significant reslationship between insulin resistance and infertility, hirsustism, and acne (p>0,05). Keyword : PCOS, Insulin Resistance, Amenorrhea, Oligomenorrhea, Infertility, Obesity, Hirsustism, Acne, Alopecia, Achanthosis Nigricans

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