THE POTENTIAL OF LIMA BEAN (Phaseolus lunatus L.) AND PATIN FISH (Pangasius hypophthalmus) IN REPAIRING SKIN HISTOLOGICAL STRUCTURE IN MALNUTRITION-INDUCED MALE RATS

Putri, Fadilatul Rahmi (2025) THE POTENTIAL OF LIMA BEAN (Phaseolus lunatus L.) AND PATIN FISH (Pangasius hypophthalmus) IN REPAIRING SKIN HISTOLOGICAL STRUCTURE IN MALNUTRITION-INDUCED MALE RATS. S1 thesis, Universitas Andalas.

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Abstract

Inadequate protein intake can lead to malnutrition, which impacts skin structure integrity. In West Sumatra, the prevalence of protein malnutrition reached 23.6% in 2024, exceeding the high-category threshold (>20%). This study aimed to assess the effectiveness of a combination of lima bean and patin fish flour (LBPF) in improving the skin histological structure in malnourished male Wistar rats. Rats were divided into five groups: normal (P1), malnourished (P2), malnourished with standard feed (P3), and two LBPF supplementation groups receiving 31.71% protein (P4) and LBPF 39.42% protein (P5), respectively. Parameters analyzed included epidermal and dermal thickness, fibroblast cells count, collagen fibers density, and inflammatory cells count. Results showed that the administration of 39.42% protein LBPF yielded the best effects, increasing epidermal thickness by approximately 1.4 times and dermal thickness by 2.8 times compared to the malnourished group. Furthermore, the fibroblast cell counts and collagen density increased to near-normal levels. The inflammatory cell counts also significantly decreased, by approximately 2.6 times compared to the malnourished group. Overall, these results indicate that high-dose LBPF supplementation has the potential to repair skin damage caused by malnutrition by enhancing tissue structure and reducing inflammatory responses.

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