EFFECT OF BLACK SOLDIER FLY (Hermetia illucens) LARVA OIL ON BLOOD PROFILE AND LUNG HISTOPATHOLOGY IN MICE EXPOSED TO CIGARETTE SMOKE

Hasanah, Syarifatul (2025) EFFECT OF BLACK SOLDIER FLY (Hermetia illucens) LARVA OIL ON BLOOD PROFILE AND LUNG HISTOPATHOLOGY IN MICE EXPOSED TO CIGARETTE SMOKE. S1 thesis, Universitas Andalas.

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Abstract

Exposure to cigarette smoke has been reported to trigger oxidative stress and inflammatory responses, which contribute to various chronic and degenerative diseases. This study aimed to examine the effect of Black Soldier Fly (Hermetia illucens) larval oil on the blood profile and lung histopathology of mice exposed to cigarette smoke in vivo. A total of 30 adult male mice were randomly assigned to six treatment groups for 30 days: P0 without treatment (control), P1 (exposure to 2 cigarettes/day), P2 (oil 5 ml/kg BW), P3 (cigarette + oil 2.5 ml/kg BW), P4 (cigarette + oil 5 ml/kg BW), and P5 (cigarette + oil 10 ml/kg BW). Oral administration of BSF larval oil for 30 days did not produce a significant effect on the blood profile of mice exposed cigarette smoke. However, BSF larval oil significantly improved lung histopathology, particularly by reducing septal thickening and inflammatory cell infiltration at a dose of 2.5 ml/kg BW. These results suggest the potential of BSF larval oil in mitigating lung damage induced by cigarette smoke exposure. Further studies with longer treatment durations and a narrower dose range around 2.5 ml/kg BW are recommended.

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