In Vitro and In Silico Study on Antioxidant Activity of Sumatra Wild Turmeric (Curcuma sumatrana, Zingiberaceae)

Petrovsky, Ivan (2025) In Vitro and In Silico Study on Antioxidant Activity of Sumatra Wild Turmeric (Curcuma sumatrana, Zingiberaceae). S1 thesis, Universitas Andalas.

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Abstract

Oxidative stress is a state in which pro-oxidative processes surpass antioxidant defenses due to an imbalance of oxidants and antioxidants with prevalence of related diseases increasing globally. Current sources of antioxidants still depend on synthetic drugs and tend to have side effects. Thus, alternative sources of antioxidants are needed that have less risk of side effects. The endemic plant of Sumatra, Curcuma sumatrana is reported to have compounds that have potential antioxidant activity. This study aims to determine the antioxidant activity of ethanol extract of C. sumatrana using in vitro and in silico approaches. DPPH, ABTS and FRAP are the methods used to determine primary and secondary antioxidant activity. In silico studies involve predictive oral uptake test, bioactivity prediction and molecular docking. In vitro results showed that through DPPH, ABTS and FRAP methods, the ethanol extract of C. sumatrana has strong, weak and moderate activity respectively . In addition, 9,10-Epoxy-12-octadecenoate was identified as the most potential compound because it has a high binding affinity to the allosteric sites of GPx, SOD, Keap1-Nrf2. However, in vitro approaches through antioxidant enzymes and in vivo experiments are needed.

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