Perbedaan Kadar Interleukin 6 (IL-6) Serum pada Kehamilan Normal Trimester 1 dan Abortus Spontan di Rumah Sakit di Kota Padang

Vella, Amalia (2023) Perbedaan Kadar Interleukin 6 (IL-6) Serum pada Kehamilan Normal Trimester 1 dan Abortus Spontan di Rumah Sakit di Kota Padang. Diploma thesis, Universitas Andalas.

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Abstract

In spontaneous abortion cases without previously known predisposing factors, an increase pro-inflammatory cytokines, especially interleukin 6 (IL-6), found in local and systemic specimens compared to normal 1st -trimester pregnancies. Therefore, IL-6 is thought to have a role in implantation failure in early pregnancy resulting in spontaneous abortion. However, research on serum IL-6 levels in spontaneous abortion patients is still limited in Indonesia. This study aims to determine the difference in serum IL-6 levels in normal pregnancy 1 st - trimester and spontaneous abortion in hospitals in Padang City. This study is an analytical study with a cross-sectional design using secondary data of 21 blood serum samples from each research group at the Biomedical Laboratory of FK Unand which have been taken from the Obstetrics and Gynecology Polyclinic, PONEK Dr. M. Djamil Hospital Padang, Andalas University Hospital, and Dr. Reksodiwiryo Hospital Padang. Samples were collected using a consecutive sampling technique. A serum examination was performed with the ELISA technique. Bivariate data analysis using Mann-Whitney statistical test based on data type and distribution. The results showed that the mean value of serum IL-6 levels was 280,56 ng/L in the normal pregnancy group in the 1st -trimester and the median value of the spontaneous abortion group was 279,78 ng/L. There was no significant difference in serum IL-6 levels in normal pregnancy in the 1st -trimester and spontaneous abortion (p = 0,980). This study concluded that there was no difference in serum IL-6 levels between patients with normal pregnancy in the 1st -trimester and spontaneous abortion in hospitals in Padang City.

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