ELUSIDASI STRUKTUR SENYAWA STEROID DARI KULIT BATANG Filicium decipiens DAN AKTIVITAS ANTIOKSIDAN FRAKSI

AYU, MUTHIA (2015) ELUSIDASI STRUKTUR SENYAWA STEROID DARI KULIT BATANG Filicium decipiens DAN AKTIVITAS ANTIOKSIDAN FRAKSI. Masters thesis, Universitas Andalas.

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Abstract

The aim of the study was to isolate and structure elucidate compound from extract of Filicium decipiens stem bark, Sapindaceae family, to determination antioxidant activity of fractions. A stigmasta-7,22-dien-3-ol (spinasterol) was isolated from the Filicium decipiens, Sapindaceae family. The fractionation of ethyl acetate stem bark extracts by colomn chromatography led to the isolation of Compound 1 (32 mg). The white powder of Compound 1 had melting point 168.1 – 168.3°C. The structure was established on the basis of UV, IR, NMR spectral data and by comparison with literature data. Methanol and ethyl acetate fractions were showed active antioxidant with IC50 value of 33.85 μg/mL and 15.62 μg/mL in the DPPH radical scavenging method. Keywords : Filicium decipiens, Sapindaceae, Steroid, Antioxidant, DPPH

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