Hubungan ekspresi Ki-67 dengan varian histopatologik karsinoma sel basal di kulit

Silvi, Yelitha (2016) Hubungan ekspresi Ki-67 dengan varian histopatologik karsinoma sel basal di kulit. Masters thesis, Universitas Andalas.

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Abstract

Latar belakang Karsinoma sel basal (KSB) merupakan keganasan kulit tersering pada manusia. Berbagai penelitian faktor risiko dihubungkan dengan perilaku KSB. Faktor-faktor tersebut menyebabkan kerusakan pada tingkat DNA yang mengakibatkan proliferasi sel meningkat. Proliferasi sel merupakan kunci utama progresi tumor yang dapat dinilai dengan ekspresi Ki-67. Studi sebelumnya menunjukkan terdapat hubungan antara penanda proliferasi Ki-67 dengan varian histopatologik KSB, tetapi hal ini masih kontroversi. Tujuan Menilai indeks proliferasi Ki-67 pada varian histopatologik KSB. Metode Sampel yang digunakan sebanyak 40 yang terdiri atas 20 sampel KSB agresif dan 20 sampel KSB non agresif. Setiap sampel diwarnai dengan pewarnaan imunohistokima (IHK) Ki-67 dan dinilai indeks proliferasinya. Hasil Ekspresi Ki-67 positif 2 paling banyak ditemukan pada KSB agresif yaitu 90% dan ekspresi Ki-67 yang positif 1 paling banyak ditemukan pada KSB non agresif yaitu 75%. Kesimpulan Terdapat hubungan bermakna antara ekspresi ki-67 dengan varian histopatologik KSB, dimana KSB agresif memiliki ekspresi Ki-67 yang lebih tinggi dibandingkan KSB non agresif. Secara statistik ditemukan hubungan yang bermakna dengan nilai p<0,05. Kata kunci Varian histopatogik KSB, KSB agresif, KSB non agresif, Ki-67, indeks proliferasi. ABSTRACT Background Basal cell carcinoma (BCC) is a common skin malignancy in human. Various studies of risk factors associated to the behavior of BCC. These factors cause damage to the DNA level which cause in increasing of cell proliferation. Cell proliferation is a key tumor progression as assessed by Ki-67 expression. Previous studies have shown there is a relationship between the proliferation marker Ki-67 and histopathological variants BCC, but it is still controversial. Objectives Assessing the Ki67 proliferation index on histopathology variants BCC. Method The sample used 40 consisting of 20 samples of aggressive BCC and 20 samples of non aggressive BCC. Each sample was stained by immunohistochemical and assessed Ki-67 proliferation index. Result The expression of Ki-67 positive two most commonly found in aggressive BCC is 90% and the expression of Ki-67 positive one most commonly found in non-aggressive BCC is 75%. Conclusion There is a significant relationship between the expression of Ki-67 with histopathological variant of BCC, where aggressive BCC expression of Ki-67 has a higher than non-aggressive BCC. Statistically significant relationship with p<0,05. Key words Varian histopathology of BCC, aggressive BCC, non aggressive BCC, Ki-67, proliferation index

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