Counteractive Effect Of Corn Silk Ethanol Extract Againts Neurotoxic Effects Of Tartrazine On Mice Brain

Devani, Maharani Rizal (2022) Counteractive Effect Of Corn Silk Ethanol Extract Againts Neurotoxic Effects Of Tartrazine On Mice Brain. Diploma thesis, Universitas Andalas.

	Text (ABSTRACT) ABSTRACT.pdf - Published Version Download (138kB)
	Text (I. INTRODUCTION) I. INTRODUCTION.pdf - Published Version Download (56kB)
	Text (V. CONCLUSION AND SUGGESTION) V. CONCLUSION AND SUGGESTION.pdf - Published Version Download (48kB)
	Text (BIBLIOGRAPHY) BIBLIOGRAPHY.pdf - Published Version Download (186kB)
	Text (UNDERGRADUATE THESIS FULL TEXT) UNDERGRADUATED THESIS FULL TEXT.pdf - Published Version Restricted to Repository staff only Download (1MB)

Abstract

Tartrazine is a popular synthetic food coloring. Although it’s a legally recommendation by the government, long time exposure of high dose of tartrazine cause decrease neurotransmitter and natural antioxidant in brain tissue, also could increase oxidative stress biomarkers. There is potential from the cornsilk, there have a natural antioxidant such as flavonoid and phenolic acid. This study aims to see the effects of cornsilk extract in counteracting the decrease in intelligence (cognitive, spatial, curiosity, and social interaction), the effects of the cornsilk extract on malondyaldehyde levels of brain tissue and the effects of the cornsilk extract in counteracting brain tissue degeneration in tartrazine treated on mice. This study used a completely randomized design method consisting of 4 treatments, Negative Control (no tartrazine and extract), Positive Control (given 700 mg/kg BW of tartrazine), first treatment group of mice given 700 mg/kg BW of tartrazine and 500 mg/kg BW of cornsilk extract, and second treatment group of mice given 700 mg/kg BW of tartrazine and 1000 mg/kg BW of cornsilk extract for 28 days orally. The results show that there are several compounds such as Cyclooctane-d16, Trichloroacetic Acid, Deuterated Chloroform, Tetradecamethyl-Cycloheptasiloxan, and Hexadecamethyl-Cyclooctasiloxane. The administration of corn hair extract is able to maintain cognitive intelligence in curiosity tests, prevent degeneration of nucleic cortex cells, as well as significantly suppress the accumulation of malondialdehyde in tartrazine-induced mice. These findings suggest that corn hair extract has properties in protecting the structure and function of the nervous system from damage caused by tartrazine.

Actions (login required)

View Item