EFFECT OF JICAMA (Pachyrhizus erosus L.) FIBER IN HIGH-FAT DIET ON INSULIN AND FIBROBLAST GROWTH FACTOR 21 IN MICE (Mus Musculus)

Yunita, Astrina (2022) EFFECT OF JICAMA (Pachyrhizus erosus L.) FIBER IN HIGH-FAT DIET ON INSULIN AND FIBROBLAST GROWTH FACTOR 21 IN MICE (Mus Musculus). Diploma thesis, Universitas Andalas.

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Abstract

ABSTRACT A high-fat diet (HFD) is one of detrimental factors contributing in epidemic of obesity. Obesity is closely associated with the development of other health problems including elevated triglyceride levels disease and diabetes. This study aimed to analyze the effects of Jicama fiber on blood glucose levels before and after treatment, insulin tolerance, insulin levels, FGF21 levels and FGF21 mRNA expression in liver in mice fed with High-Fat Diet (HFD). This study was conducted for 4 months from May until August 2021, in Animal Physiology Research Laboratory, Department of Biology, Faculty of Mathematics and Natural Sciences, Andalas University, Padang. This study used experimental method and with a completely randomized design with 4 treatments and 6 replications for 12 weeks. The mice were treated with different diet, Normal Diet (ND), HFD, HFD combined with 10% and 25% Jicama fiber. The results revealed that Jicama fiber had significant different in decrease blood gluoce levels, inhibit hyperinsulinemia and insulin intolerance. Moreover, Jicama fiber could reduce FGF21 level in inhibiting hyper-FGF21 and Jicama fiber could increase FGF21 mRNA expression in mice fed with HFD. Therefore, Jicama fiber exerted health benefits against HFD and obesity. Keywords: Dietary Fiber, Obesity, Blood Glucose, Insulin, FGF21

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