KORELASI KADAR FERRITIN DENGAN KADAR BRAIN DERIVED NEUROTROPIC FACTOR (BDNF) PADA PREEKLAMSIA

Dona, Mirsa Putri (2020) KORELASI KADAR FERRITIN DENGAN KADAR BRAIN DERIVED NEUROTROPIC FACTOR (BDNF) PADA PREEKLAMSIA. Masters thesis, Universitas Andalas.

Preview	Text (Cover dan Abstrak) 1. Cover & Abstrak.pdf - Published Version Download (74kB) | Preview
Preview	Text (BAB I ,Pendahuluan) 2. BAB I.pdf - Published Version Download (187kB) | Preview
Preview	Text (BAB VII PENUTUP) 3 BAB VII.pdf - Published Version Download (50kB) | Preview
Preview	Text (DAFTAR PUSTAKA) 4.Daftar Pustaka.pdf - Published Version Download (176kB) | Preview
	Text (TESIS FULL TEXT) 5. Tesis Full dr Dona Mirsa Putri.pdf - Published Version Restricted to Repository staff only Download (1MB) | Request a copy

Abstract

Background and Objective: Iron deficiency anemia that followed by low serum ferritin levels in early pregnancy has an indirect impact on decreasing the expression of Brain Derived Neurotrophic Factor (BDNF) in the maternal hippocampus. BDNF together with its receptor tyrosine kinase B (TrkB) induced the expression of metalloproteinase-9 (MMP-9) which plays an important role in blastocyst implantation, trophoblast invasion and placental development. Decreasing BDNF levels can interfere with those process which caused imbalance of pro-angiogenic and anti-angiogenic factors such as VEGF, PIGF, sFlt1 and sEng that leads to preeclampsia. This study aims to determine the correlation between ferritin and BDNF serum levels in preeclampsia. Methods: This was an observasiotnal study with a cross-sectional design involving above 20 term pregnant women who were diagnosed with preeclampsia. A total of 66 sample were taken from Dr. M. Djamil Padang Hospital and examined for ferritin and BDNF serum levels using the ELISA method. The data normality test was performed using the Kolmogorov-Smirnov test, followed by the Pearson correlation test and simple linear regression test. Result: Ferritin serum level was normal (181.76 ± 212.08 ng/ml). The mean of BDNF levels were found to be lower than normal pregnancies (0.505 ± 0.314 ng/ml) (normal range of BDNF levels was 8-46 ng/ml). There was an insignificant positive correlation between ferritin levels and serum BDNF levels, with correlation coefficient (R) 0.147 (weak correlation) (p = 0.240). Conclusion: Ferritin serum level have positive correlation with BDNF serum level in preeclampsia.

Actions (login required)

View Item