Oshin, Amirah Rafi (2021) PENGARUH PEMBERIAN ISOLAT KATEKIN GAMBIR (Uncaria gambir Roxb) TERHADAP KADAR GLUKOSA SERUM TIKUS (Rattus norvegicus) YANG DIINDUKSI DIET TINGGI LEMAK. Diploma thesis, Universitas Andalas.
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Abstract
Catechin isolates of gambier (Uncaria gambir Roxb) is an active substance isolate from gambier extract that acts as an antioxidant and affects insulin sensitivity. This study aims to determine the effect of gambier’s catechin isolate (Uncaria gambir Roxb) on glucose levels in rats (Rattus norvegicus) by inducing a high-fat diet. This study was a true experimental with a post-test only control group design. This study used 30 rats divided into five groups; negative control group (K-), positive control grup (K +), treatment 1 (P1), treatment 2 (P2), and treatment 3 (P3). Groups K +, P1, P2, P3 were induced with a high-fat diet, then group of P1, P2, P3 were given catechin isolates of gambiers by dosages; 10 mg / kgBB / day20 mg / kgBB / day, and 40 mg / kgBB / day for 14 days. Blood glucose levels were measured by using the enzymatic method Glucose Oxidase - Peroxidase Aminoantypirin (GOD-PAP). Kruskal Wallis and Post Hoc Mann-Whitney-Test were used for data analysis. The Average of glucose level in K-, K+, P1, P2, and P3 was 99.37 ± 17.03 mg / dl; 136.78 ± 19.68 mg / dl; 124.72 ± 9.46 mg / dl; 116 ± 5 ,63 mg / dl; and 107.37 ± 7.29 mg / dl, respectedly. The variety of this study presented catechin isolates of gambiers at glucose levels in the P3 group with positive control (p = 0.006), treatment 1 (p = 0.016) and treatment 2 (p = 0.037). The conclusion of this study is that catechin isolates of gambir can affect blood glucose levels.
| Item Type: | Thesis (Diploma) |
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| Primary Supervisor: | dr. Rauza Sukma Rita Ph.D |
| Uncontrolled Keywords: | isolat katekin, gambir, diet tinggi lemak, hiperglikemia |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Fakultas Kedokteran |
| Depositing User: | S1 Pendidikan Kedokteran |
| Date Deposited: | 04 Feb 2021 04:43 |
| Last Modified: | 04 Feb 2021 04:43 |
| URI: | http://scholar.unand.ac.id/id/eprint/69560 |
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