HUBUNGAN EKSPRESI NEGATIF MLH-1 DENGAN GAMBARAN KLINIKOPATOLOGIK KARSINOMA KOLOREKTAL

Selly, Alinta Syukri (2018) HUBUNGAN EKSPRESI NEGATIF MLH-1 DENGAN GAMBARAN KLINIKOPATOLOGIK KARSINOMA KOLOREKTAL. Masters thesis, Universitas Andalas.

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Abstract

Correllation Between MLH-1 Negative Expression and Clinopathologic Features of Colorectal Carcinoma ABSTRACT Selly Alinta Syukri Colorectal carcinoma (CRC) is a malignant neoplasm arised from epithelial of colorectal crypt and mucosa. Colorectal carcinoma incidence continue to increase year after year. Globally, colorectal cancer is the third most common cancer in men, the second most common cancer in woman and the fourth leading cause of cancer death. Colorectal carcinoma survival tends to be poorer particularly in developing countries.. Microsatellite instability (MI) pathway is one of carcinogenesis pathway of CRC that was characterized by deletions or insertions within a number of repeated nucleotide units due to defects in DNA mismatch repair gene. Microsatellite instability CRC gives new hope, with its better prognosis and the chemotherapy adjuvant respons is different from other pathway of CRC. The problem of the majority of MI CRC is on MLH-1 gene. that often associated with clinicopathologic features, such as age, sex, tumor location and histopatologic subtype. Clinicopathologic features and MI status, by showing negative expression of MLH-1 would increase the succesfull of therapy. The purpose of this study was finding the correlation of negative expression of MLH-1 with clinicopathological features of CRC. This was a cross sectional study in Padang with 50 cases of colorectal carcinoma which had been diagnosed in 4 Pathology Anatomy Laboratory in West Sumatera. Samples were obtained from parafin block of tissue from surgery and have been classified into age, sex, tumor location and been reevaluated about histopathological subtype of colorectal carcinoma. Immunohistochemistry staining were done to find presence/ absence of MLH-1 expression in tumor cell nuclei. Chi square-test, t-test and one way annova bivariate statistical analysis were used with p value<0.05 were considered significant. Negative expression of MLH-1 is found in 17 cases (34%). There was unsignificant correlation between MLH-1 expression with age, sex, tumour location (subsequent p value 0,277, 0,557 and 0,093) and significant correlation with histopathologic subtype of colorectal carcinoma (p=0,002). Conclusion, the MLH-1negative expression was mostly found in the age of > 40 years old, male, proximal tumour location and mucinous carcinoma subtype. Keyword: Colorectal carcinoma, MLH-1 negative expression, age, sex, tumour location and histopathologic subtype.

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