Karakterisasi Dispersi Padat Piperin Dan Gelucire 44/14 Dengan Metode Peleburan

Alfauzan, Saputra (2018) Karakterisasi Dispersi Padat Piperin Dan Gelucire 44/14 Dengan Metode Peleburan. Diploma thesis, Universitas Andalas.

Text (Cover dan Abstrak)
cover dan abstrak.pdf - Published Version

Download (44kB) | Preview
[img] Text (BAB 1)
Bab 1.pdf - Published Version

Download (264kB)
[img] Text (BAB Penutup)
Bab 5.pdf - Published Version

Download (31kB)
Text (Daftar Pustaka)
Daftar Pustaka.pdf - Published Version

Download (160kB) | Preview
[img] Text (Full Skripsi)
Tugas Akhir Fix.pdf - Published Version
Restricted to Repository staff only

Download (2MB)


Piperin is one of the major compound of black pepper plants (Piper ningrum). This compound has many pharmacological effects, namely as an anti-inflammatory, analgesic, anti-depressant, anti-leukemia, anti-oxidant and citoprotective. Piperine has low solubility in water, this causes its bioavailability also low, so a strategy is needed to increase its solubility and bioavailability. The method used in this study is the melting of solid dispersions with polymer Gelucire 44/14. In this research piperine-Gelucire 44/14 solid dispersion with 3 ratio (1:1, 2:1; 1:2) and physical mixture (1:1). Solid dispersion and piperine-Gelucire 44/14 physical mixture were characterized by XRD diffraction analysis, differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and fourier transform infrared spectroscopy (FTIR). From the results of X-ray diffraction shows the reduced intensity of the peak interference produced. From the results of DSC analysis it was found that the peak intensity was reduced. The SEM test showed that piperine crystals were dispersed in gelucire 44/14 so that the solid dispersion was in amorphous form. In the FTIR test the peak, Indicates the formation of hydrogen bonds. This bond prevents the recrystallization process from piperine. The highest solubility increase was in the 1:2 solid dispersion formula with an increase in solubility of 3.32 higher than piperine. The highest dissolution increase was in formula 1:2 with 4.03 dissolution efficiency increase from piperine.

Item Type: Thesis (Diploma)
Primary Supervisor: Dr. Salman, M.Si., Apt
Uncontrolled Keywords: piperin, Gelucire 44/14, solid dispersion, melting method, solubility.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Farmasi
Depositing User: s1 Fakultas Farmasi
Date Deposited: 30 Oct 2018 10:05
Last Modified: 20 Jan 2023 09:19
URI: http://scholar.unand.ac.id/id/eprint/40437

Actions (login required)

View Item View Item