HUBUNGAN KADAR CHEMERIN DENGAN HOMEOSTASIS MODEL ASSESMENT INSULIN RESISTANCE (HOMA-IR) PADA REMAJA OBESITAS

silvy, dioni (2016) HUBUNGAN KADAR CHEMERIN DENGAN HOMEOSTASIS MODEL ASSESMENT INSULIN RESISTANCE (HOMA-IR) PADA REMAJA OBESITAS. Masters thesis, Universitas Andalas.

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Abstract

ASSOCIATED CHEMERIN LEVEL AND HOMEOSTASIS MODEL ASSESMENT INSULIN RESISTANCE IN OBESE ADOLESCENT By: Silvy dioni (11212102039) Supervised by: dr. Eka Agustia Rini,SpA(K), Prof.DR.Eti Yerizel, M.Si. ABSTRACT Background: Childhood obesity associated with an increased risk for metabolic syndrome, such as insulin resistance. Homestatic model assesment insulin resistance (HOMA-IR) is a chemical marker widely used for insulin resistance. Chemerin is a 18 kDa protein produced by adipose tissue, function as chemoatractant plays an important role contributing to the development of inflammation and insulin resistance. Objective. To determine assosiation chemerin level and HOMA-IR in obese adolescent. Methods. This was a cross-sectional study and conducted in three Senior High School in Padang. Twenty eight obese adolescents and 28 control were enrolled in the study. The age of the subjects ranged from 14-18 years. Obesity criteria was measure based on body mass index (BMI). Fasting serum glucose level measured by glucose hexokinase fotometrik method and serum insulin was measured by chemiluminessence immunoassay method. Plasma chemerin was measured with enzyme-linked immunosorbent assay (ELISA). The insulin resistance index was estimated from fasting serum insulin and glucose level using the formula.Data was analyzed using correlation test and t-test, P<0,05 was significant. Result. The plasma chemerin level was higher in the obese than in the control group 121,52 (SD 2,09) ng/ml vs 97,23 (SD 2,41) ng/ml,p: 0,001, and the insulin resistance group had higher plasma chemerin level than non resistance group 133,1(SD 19,24) vs 115,09 (SD 19,52), p: 0,027. There is a weak correlation with the value chemerin levels HOMA-IR in obesity (r = 0.382; p = 0.045) and weak correlation with value chemerin levels HOMA-IR in obese insulin resistance (r = 0.297; p = 0.405). Conclusion. There is a weak correlation with the value chemerin levels HOMA-IR in obesity and insulin resistance, and weak correlation with the value chemerin level HOMA-IR in obese insulin resistance. Key Words. Obese adolescents, insulin resistance, plasma chemerin

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