THE DIFFERENCES LEVELS OF INTERLEUKIN-8 AND C-REACTIVE PROTEIN BETWEEN AT TERM PREMATURE RUPTURE OF MEMBRANES AND NORMAL PREGNANCIES

Nikmatullah, Wahida (2016) THE DIFFERENCES LEVELS OF INTERLEUKIN-8 AND C-REACTIVE PROTEIN BETWEEN AT TERM PREMATURE RUPTURE OF MEMBRANES AND NORMAL PREGNANCIES. Masters thesis, Universitas Andalas.

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Abstract

Premature rupture of membranes (PROM) is an important issue in the Problem of obstetric that causes of maternal and infant mortality. One of the risk factors occurred is infection. The response to infection such as inflammatory reaction will stimulate the production of proinflammatory cytokines Interleukin-1(IL-1), Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), Iinterleukin-8 (IL-8) and C-Reactive Protein (CRP). The purpose of this study was to determine the difference levels of interleukin-8 and C-reactive protein between term premature rupture of membranes and normal pregnancies. The study design was cross-sectional comparative at Dr. Achmad Mochtar hospital Bukittinggi and Biomedical laboratory Faculty of Medicine Andalas University in April 2015-June 2016. Samples in this study are 42 aterm pregnancy women were selected by consecutive sampling, samples was divided with 21 term premature rupture of membranes and 21 normal pregnant women. IL-8 dan CRP levels measured with ELISA. Data were analiyzed using analysis of Kolmogrove Smirnov. The average levels of IL-8 in term PROM was 1442.46 ± 995.27 pg/ml and the average levels of IL-8 in normal pregnancies was 392.16 ± 328.29 pg/ml (p = 0.002). The average of CRP levels in term PROM was 0.057 ± 0.058 mg/L and the average CRP levels in normal pregnancies was 0.015 ± 0.019 mg/L (p = 0.006). There were significant differences in the average levels of IL-8 and CRP between term PROM and normal pregnancies. In conclusion, There were significant differences in the levels of IL-8 and CRP in term PROM and normal pregnancies. Keywords: Interleukin-8, C-Reactive Protein, Premature Rupture of Membranes, Normal pregnancy

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