EFFECT OF DIMEFLUTHRIN-BASED MOSQUITO COILS ON PREGNANCY OF MICE (Mus musculus) SWISS WEBSTER

Chika, Afrilia Ikbal (2022) EFFECT OF DIMEFLUTHRIN-BASED MOSQUITO COILS ON PREGNANCY OF MICE (Mus musculus) SWISS WEBSTER. Diploma thesis, Universitas Andalas.

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Abstract

Synthetic pyrethroids are a class of current-use pesticides produced for pest control in agricultural and residential areas, widely used as active ingredients in mosquito repellents (MR) owing to their relatively low toxicity to mammals. Dimefluthrin is a synthetic pyrethroid with claim to be safe and harmless to mammals. Despite that claim, it is remain unknown whether mosquito coil with active ingredients dimefluthrin has a potential risk to pregnant mice. This study aimed to investigate teratogenic potential of dimefluthrin when administered to pregnant mice via inhalation at different gestational stages. This study was conducted for 3 months from January until March 2022, in Animal structure and development research laboratory, Biology Department, Faculty of Mathematics and Natural Science, Andalas University. This study used experimental methods with 4 treatments and 6 replications. This study was used mosquito coils with the active ingredient dimefluthrin 0.031% and exposed to pregnant mice for different age of pregnancy. The result showed that mosquito coil with active ingredient dimefluthrin has teratogenic effect by causing a decreased of the percentage of live fetuses and increased the percentage of dead fetuses and in all group and significant on the exposure on the seventh until the eighteenth day of pregnancy, reduced fetal weight, length and volume especially on the seventh to eighteenth day of gestation, and caused fetal abnormalities in the form of hemorrhage and was highest at three hours of exposure every day during pregnancy.

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