eprintid: 466866
rev_number: 54
eprint_status: archive
userid: 22
dir: disk0/00/46/68/66
datestamp: 2024-05-20 04:27:13
lastmod: 2024-05-20 04:27:13
status_changed: 2024-05-20 04:27:13
type: thesis
metadata_visibility: show
creators_name: Wina, Asiva Chissa Putri
creators_id: 2010311011
title: Pengaruh Susu Fermentasi Stater Lactococcus Lactis D4 Asal Dadih Terhadap Aktivitas Enzim Katalase dan Kadar Malondialdehid Tikus Model Ikterus Obstruktif
ispublished: unpub
subjects: R1
divisions: pd
full_text_status: restricted
note: Prof. Dr. Eti Yerizel, MS
abstract: Ikterus obstruksi memiliki angka kematian pasca operasi yang tinggi akibat tingginya aktivitas senyawa radikal bebas yang menyebabkan kerusakan hepar yang tetap berlanjut. Susu fermentasi starter Lactococcus lactis D4 asal dadih merupakan probiotik yang berpotensi memperlambat kerusakan hepar dan menurunkan aktivitas senyawa radikal bebas. Tujuan penelitian ini untuk mengetahui pengaruh pemberian susu fermentasi starter Lactococcus lactis D4 asal dadih terhadap kadar MDA serta aktivitas enzim katalase serum pada tikus model ikterus obstruktif.
Penelitian ini adalah penelitian eksperimental yang dilakukan secara post test only randomized control group design. Penelitian ini melibatkan 18 ekor tikus Rattus novergicus galur Wistar model ikterus obstruktif yang dibagi menjadi 3 kelompok yaitu kontrol negatif (K-), kontrol positif (K+), dan kelompok perlakuan (P) susu fermentasi starter Lactococcus lactis D4 asal dadih dosis 0,36 ml/200 grBB selama 7 hari. Penelitian ini kemudian akan menilai aktivitas enzim katalase serum serta kadar MDA dari tikus model ikterus obstruktif.
Hasil penelitian ini menunjukkan rerata aktivitas enzim katalase (unit/mg) adalah K-: (5.38 ± 0.31), K+ (4.98 ± 0.47), P (5.08 ± 0.24). Tidak terdapat perbedaan bermakna aktivitas enzim katalase serum tikus (p>0,05). Rerata kadar MDA (nmol/ml) adalah K- (1.76 ± 0.07), K+ (2.46 ± 0.10), P (1.80 ± 0.08). Terdapat perbedaan bermakna kadar MDA tikus (p<0,05).
Pemberian susu fermentasi starter Lactococcus lactis D4 berpengaruh dalam memperbaiki fungsi hepar yang ditandai dengan peningkatan aktivitas enzim katalase dan penurunan kadar MDA tikus.
date: 2024-03-14
date_type: submitted
institution: Universitas Andalas
department: Fakultas Kedokteran
thesis_type: diploma
thesis_name: other
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citation:   Wina, Asiva Chissa Putri  (2024) Pengaruh Susu Fermentasi Stater Lactococcus Lactis D4 Asal Dadih Terhadap Aktivitas Enzim Katalase dan Kadar Malondialdehid Tikus Model Ikterus Obstruktif.  Diploma thesis, Universitas Andalas.   
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