HUBUNGAN JUMLAH SEL CD4 DENGAN INFEKSI Cryptosporidium sp. PADA PENDERITA HIV/AIDS DI SUMATERA BARAT SECARA MIKROSKOPIS DAN PCR

Goldha, Faroliu Peadutu (2019) HUBUNGAN JUMLAH SEL CD4 DENGAN INFEKSI Cryptosporidium sp. PADA PENDERITA HIV/AIDS DI SUMATERA BARAT SECARA MIKROSKOPIS DAN PCR. Masters thesis, Universitas Andalas.

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Abstract

Opportunistic infections are infections that occur due to a decrease in the immune system. This infection can be fatal in people with a weak immune system, especially people with HIV/AIDS due to a decrease in the number and function of CD4 cells so that it can cause secondary infections. Cryptosporidium sp. is one of the opportunistic intestinal protozoa that is generally asymptomatic and is self-limited in immunocompetent individuals, but in individuals with an immune deficiency often results in chronic diarrhea, leading to dehydration and malnutrition which can increase mortality and morbidity in HIV sufferers. The purpose of this study was to determine the relationship of CD4 cell counts with Cryptosporidium sp. in people with HIV/AIDS in West Sumatra. Observational study with cross-sectional design on 50 fecal samples of HIV/AIDS patients with a CD4 cell count of ≤350 cells/µl from March - July 2019. Examination of Cryptosporidium sp. performed by staining Ziehl Neelsen in the Parasitology Laboratory and molecular examination using PCR conducted at the Microbiology Laboratory of the Faculty of Medicine, Andalas University, CD4 cell counts were obtained from medical records and data analysis using the Independent Sample T-Test and Chi-Square. The results obtained 2 respondents (4%) positive infected with Cryptosporidium sp., There is a significant relationship between CD4 cell counts with Cryptosporidium sp. infection, p-value = 0.001 (p> 0.05) and there is a significant relationship between Cryptosporidium sp. infections with a history of diarrhea, p-value = 0.045 (p> 0.05). From this study, it can be concluded that there is a relationship between CD4 cell counts and Cryptosporidium sp.

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