PENGARUH EKSTRAK ETANOL DAUN RANTI (Solanum nigrum Linn.) TERHADAP KADAR GLUKOSA DARAH MENCIT PUTIH JANTAN DIABETES YANG DIINDUKSI DENGAN ALOKSAN

Amora, Lesi Fitri Novia (2011) PENGARUH EKSTRAK ETANOL DAUN RANTI (Solanum nigrum Linn.) TERHADAP KADAR GLUKOSA DARAH MENCIT PUTIH JANTAN DIABETES YANG DIINDUKSI DENGAN ALOKSAN. S1 thesis, Universitas Andalas.

Text (Skripsi Ful Teks) OK S1 Farmasi 2011 Lesi Fitri Novia Amora 07131003.pdf - Published Version Restricted to Repository staff only Download (4MB)

Abstract

The effect of ethanolic extract of ranti leaves {Solanum nigrum Linn.) to the blood glucose level on diabetic mice induced by alloxan (150 mg/KgBB) has been investigated. The research was carried out experimentally using 20 male mice(4 groups) about 2-3 months old that 20-30 grams of body weight. Group I was a positive control. Group II, III, and IV where induced diabetic mice treated with extract at variabel doses of 125, 250 and 500 mg/Kg of body weight, respectively. The suspension of Solanum nigrum L. extract was administered orally once a day for 7 days. The blood glucose level, body weight,24 hour food intake, urine output, water intake, liver ratio and pancreatic ratio were determined. The study data was analyzed using one and two-ways ANOVA followed by Duncan post hock test. Results showed that the blood glucose levels in the animals treated with ranti leaves was lower compared to positive control significantly (P<0.01). This effect was followed by increased in the body weight, decreased in 24 hour food intake, urine output and water intake significantly (P<0.05). However, there was no significant effects on the liver and pancreatic ratios (P>0.01). It can be concluded that the ethanolic extract ofSolanum nigrum L. leaves reduces the blood glucose effect on induced diabetic mice.

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