Analysis of Tumor Control and Normal Tissue Complication Probability in Stage III Cervical Cancer Using Equivalent Uniform Dose with 3DCRT

Defalma, Angelica (2025) Analysis of Tumor Control and Normal Tissue Complication Probability in Stage III Cervical Cancer Using Equivalent Uniform Dose with 3DCRT. S1 thesis, Universitas Andalas.

	Text (Cover dan Abstrak) abstrak.pdf - Published Version Download (358kB)
	Text (BAB 1 Pendahuluan) BAB 1 Pendahuluan.pdf - Published Version Download (201kB)
	Text (BAB 5 Kesimpulan dan Saran) BAB 5 Penutup.pdf - Published Version Download (185kB)
	Text (Daftar Pustaka) Daftar Pustaka.pdf - Published Version Download (209kB)
	Text (Full Text) skripsi full text.pdf - Published Version Restricted to Repository staff only Download (3MB) | Request a copy

Abstract

This study aimed to evaluate dosimetric and radiobiological parameters in 24 patients with Stage III cervical cancer treated using Three-Dimensional Conformal Radiation Therapy (3DCRT) at Universitas Andalas Hospital. The physical dose quality was assessed using the Homogeneity Index (HI) and Conformity Index (CI), while biological effectiveness was analyzed using the Equivalent Uniform Dose (EUD) model. Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) were calculated based on Niemierko’s formalism. Dose-volume histogram (DVH) data were extracted from Eclipse TPS and processed with Python scripts. Results showed that HI and CI values fell within clinically acceptable standards, indicating uniform and conformal dose distributions. The mean TCP was 41.36% ± 0.31%, suggesting a moderate probability of tumor control. For NTCP, the bladder exhibited the highest risk with a mean of 83.16% ± 26.78%, often exceeding its tolerance dose (TD50 = 80 Gy). In contrast, the bowel and rectum showed lower complication probabilities, with mean NTCP values of 2.06% ± 3.00% and 0.40% ± 0.18%, respectively. These findings indicate that while 3DCRT provides satisfactory physical coverage, special attention is needed to minimize complications in organs at risk, particularly the bladder.

Actions (login required)

View Item