EFFECT OF ANTIOSTEOPOROTIC ACTIVITY OF Sargassum crassifolium EXTRACT ON ANIMAL MODELS OF BONE LOSS

Hulrahma, Mifta (2025) EFFECT OF ANTIOSTEOPOROTIC ACTIVITY OF Sargassum crassifolium EXTRACT ON ANIMAL MODELS OF BONE LOSS. S1 thesis, Universitas Andalas.

	Text (Cover and Abstract) COVER_ABSTRACT.pdf - Published Version Download (512kB)
	Text (BAB 1) BAB 1.pdf - Published Version Download (308kB)
	Text (BAB Akhir) BAB 5.pdf - Published Version Download (274kB)
	Text (Bibliography) BIBLIOGRAPHY.pdf - Published Version Download (349kB)
	Text (Thesis Fulltext) E SKRIPSI MIFTA FIX.pdf - Published Version Restricted to Repository staff only Download (8MB) | Request a copy

Abstract

Osteoporosis is a bone disease characterized by a decrease in bone mass and an increase in bone fragility. Brown algae (Sargassum crassifolium) contain bioactive compounds with the potential as anti-osteoporosis agents. This study aimed to evaluate the anti-osteoporotic potential of brown algae extract in vivo through bone histopathology and in silico through the prediction of bioactive compounds. Twenty five female Wistar rats were divided into normal, osteoporosis, two brown algae extract with doses of 350 mg/kg BW and 450 mg/kg BW, and alendronate group with doses of 5 mg/kg BW. Measurements of body weight and bone histopathology parameters, including cortical thickness, osteoblast count, medullary cavity diameter, and chondroid matrix area percentage, was conducted. The results showed that both 350 and 450 mg/kg BW brown algae extract doses significantly improved cortical thickness, osteoblast count, and chondroid matrix area percentage. However, they did not significantly affect the medullary cavity diameter. In silico analysis using PASS online identified 15 bioactive compounds with potential as anti-osteoporosis agents. In conclusion, both doses of brown algae extract were effectively increased cortical thickness, osteoblast count, and percentage of chondroid matrix area, with no significant difference observed between the two doses.

Actions (login required)

View Item