NEURORECOVERY POTENTIAL OF FLOUR FORMULATIONS FROM LIMA BEANS (Phaseolus lunatus) AND PATIN FISH (Pangasius hypopthalmus) IMPROVING CEREBRAL STRUCTURE AND COGNITIVE FUNCTION IN PROTEIN MALNOURISHED RATS

Ibrahim, Muhammad Hamdi (2025) NEURORECOVERY POTENTIAL OF FLOUR FORMULATIONS FROM LIMA BEANS (Phaseolus lunatus) AND PATIN FISH (Pangasius hypopthalmus) IMPROVING CEREBRAL STRUCTURE AND COGNITIVE FUNCTION IN PROTEIN MALNOURISHED RATS. S1 thesis, Universitas Andalas.

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Abstract

Protein malnutrition, caused by inadequate protein intake, leads to cognitive decline. In West Sumatra, its prevalence reached 25.2% in 2021, exceeding the national average. This research investigated the potential of lima beans and patin fish flour (LBPF) to improve cerebral structure and cognitive function in protein-malnourished male wistar rats. Five groups were used: normal (P1), malnourished (P2), malnourished with standard feed (P3), and malnourished treated with 7g (P4) or 14g (P5) LBPF-supplemented feed. Assessments included histopathology of the cerebral cortex and hippocampus, brain weight, MDA levels, and cognitive tests (Y-Maze, Novel Object Recognition, Morris Water Maze). The 14g LBPF dosage (P5) was most effective, significantly reducing degenerated cells in the cerebral cortex (20 times) and hippocampus (5.4 times), while increasing cerebral thickness (1.2 times) and hippocampal density (1.8 times). This dose also markedly improved performance in cognitive tests, showing a strong correlation (0.84<r<0.98) with the histopathological findings and a positive effect on brain MDA levels. In conclusion, a 14g LBPF- supplemented diet demonstrates significant neurorecovery potential in protein- malnourished rats, enhancing brain structure, reducing oxidative stress, and recovering cognitive function.

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