The Potential of Paliasa Leaf Extract (Kleinhovia hospita L.) as an Agent for Repairing the Colon Mucosa in Ulcerative Colitis Rats

Kurnia Illahi, Angga (2024) The Potential of Paliasa Leaf Extract (Kleinhovia hospita L.) as an Agent for Repairing the Colon Mucosa in Ulcerative Colitis Rats. Diploma thesis, Universitas Andalas.

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Abstract

Ulcerative colitis is an inflammatory bowel disease that affects the colonic mucosa. The leaves of Kleinhovia hospita L. contain bioactive compounds with potential to repair colonic mucosa in ulcerative colitis. This study aims to evaluate the potential of paliasa leaf extract through in silico methods as an anti-inflammatory and antioxidant, and its effect on the histopathological improvement of the colon in rats induced with colitis using 1% dextran sodium sulfate in vivo. Twenty-five male rats were divided into normal, colitis induction, sulfasalazine (100 mg/kg BW), and paliasa leaf extract groups with doses of 100 mg/kg BW and 400 mg/kg BW. Measurements of colon length, weight, diameter, mucosal thickness, and goblet cell count in colonic histology were conducted, along with observations of histopathological improvements, including reduced necrosis, inflammatory cell infiltration, submucosal edema, and increased epithelial integrity. The 400 mg/kg BW dose of paliasa leaf extract improved colon length, weight, mucosal thickness, and goblet cell count after colitis induction, and reduced damage such as necrosis, inflammatory cell infiltration, submucosal edema, and increased epithelial integrity. PASS Online analysis identified 18 bioactive compounds in the paliasa leaf extract with anti-inflammatory potential and one compound with antioxidant potential (Pa > 0.7). In conclusion, the 400 mg/kg BW dose of paliasa leaf extract effectively improved colon length, colon weight, mucosal thickness, goblet cell count, and colonic histopathology

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