ANALISIS HUBUNGAN POLIMORFISME GEN RANKL rs9594738, KONSENTRASI RANKL, DAN OSTEOPROTEGERIN SALIVA DENGAN KASUS PERSISTENSI GIGI SULUNG ANAK SUKU MINANGKABAU

Syafitri, Fuccy Utamy (2023) ANALISIS HUBUNGAN POLIMORFISME GEN RANKL rs9594738, KONSENTRASI RANKL, DAN OSTEOPROTEGERIN SALIVA DENGAN KASUS PERSISTENSI GIGI SULUNG ANAK SUKU MINANGKABAU. Doctoral thesis, Kedokteran Gigi.

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Abstract

Persistence of primary teeth can cause dental and oral problems, one of which is malocclusion. Malocclusion is a dentofacial anomaly in the form of abnormal positions of teeth in the dental arch and abnormal interjaw relations. Malocclusion can affect mastication and deglutition functions, facial balance, appearance, and psychosocial aspects (Kapil, 2021 and Elyaskhil, 2021). The resorption of alveolar bone and the roots of primary teeth involves the coordination of signaling between the dental follicle with osteoblasts and osteoclasts in the alveolar bone through the RANK/RANKL/OPG pathway. One of the most influential genes in the process of osteoclast activation and maturation is the RANKL gene (Gao et al., 2019). The expression of the RANKL gene increases in the periodontal ligament when alveolar bone teeth receive pressure or mechanical stimulation, thereby stimulating osteoclastogenesis and osteoclastic activity (Arid et al., 2019; Zhang et al., 2020). This study is an observational analytic study with a cross-sectional design. The study subjects consisted of 30 individuals with cases of primary tooth persistence and 30 individuals without cases of primary tooth persistence as the control group, with sampling conducted using the consecutive sampling method. Saliva collection of study subjects was carried out using the unstimulated method for the examination of rs9594738 RANKL gene polymorphism, and for saliva RANKL and Osteoprotegerin concentration in cases of primary tooth persistence in Minangkabau children. The results of this study indicate that female subjects were more prevalent in both groups compared to male subjects. The average age of subjects in the persistence group was 9.27 years and in the control group was 8.4 years. Sequencing results showed mutations in the persistence group where heterozygous mutant polymorphism (CT) was more prevalent than in the control group. The average concentration of saliva RANKL in the persistence group was higher compared to the control group. The average concentration of saliva Osteoprotegerin in the persistence group was higher compared to the control group. This study concludes that there is a difference in the rs9594738 RANKL gene polymorphism between the primary tooth persistence group and the control group in Minangkabau children. There is no difference in saliva RANKL concentration between the primary tooth persistence group and the control group in Minangkabau children. There is no difference in saliva Osteoprotegerin concentration between the primary tooth persistence group and the control group in Minangkabau children. There is a significant correlation between rs9594738 RANKL polymorphism, RANKL concentration, and saliva Osteoprotegerin concentration with primary tooth persistence in Minangkabau children.

Item Type:	Thesis (Doctoral)
Primary Supervisor:	Prof. Dr. drg. Nila Kasuma, M. Biomed Prof. Dr. Eti Yerizel,MS Dr. dr. Roni Eka Sahputra,Sp.OT(K)
Subjects:	R Medicine > RZ Other systems of medicine
Divisions:	Fakultas Kedokteran
Depositing User:	s3 Biomedik kedokteran
Date Deposited:	27 May 2024 03:28
Last Modified:	27 May 2024 03:28
URI:	http://scholar.unand.ac.id/id/eprint/466797

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