EFEKTIVITAS MADU GALO-GALO (Trigona sp.)DALAM MENANGKAL PENURUNAN TINGKAT KECERDASAN MENCIT AKIBAT PEMBERIAN MONOSODIUM GLUTAMAT

Fitri, Amalina Purwasih (2019) EFEKTIVITAS MADU GALO-GALO (Trigona sp.)DALAM MENANGKAL PENURUNAN TINGKAT KECERDASAN MENCIT AKIBAT PEMBERIAN MONOSODIUM GLUTAMAT. Diploma thesis, Universitas Andalas.

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Abstract

Monosodium Glutamate (MSG) is known to be capable of causing neurotoxic effects which result in decreased intelligence both in animal models and humans. Otherwise, the sugar content of honey could nourish the neurons while the antioxidants could counteract the free radicals. Both sugar and antioxidants are found in honey of stingless bee (Trigona sp.). The purpose of this study was to clarify that honey of stingless bee could prevent a decrease in the intelligence and thinning of the cerebral cortex of mice due to consumption of MSG. This research was conducted from December 2018 to March 2019 in the Laboratory of Animal Physiology and the Structure of Animal Development. MSG is mixed with drinking waters and provided ad libitum while honey was given orally every day in male 1-month-old DDY mice. Five treatments consisted of P0 (aquades), P1 (MSG), P2 (MSG + honey 20%), P3 (MSG + honey 40%), P4 (MSG + honey 60%) were deployed continously for 4 weeks. The results of the study revealed that honey of stingless bee could significantly counteract the decrease of memory intelligence, spatial intelligence, curiosity, duration of interaction as well as increase of latency time of social interaction. Histological examination showed that honey of stingless bee was effectively capable of preventing the thinning of the cerebral cortex in mice fed with MSG. The higher the dose of honey, the more effective it will be in neutralizing the impact of MSG. These findings profoundly suggest that honey of stingless bee exerts a high efficacy in protecting the structure and function of the nervous system from the MSG-induced damages.

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