HUBUNGAN POLIMORFISME GEN BACTERICIDAL PERMEABILITY INCREASING PROTEIN, CLUSTER OF DIFFERENTIATION 14, INTERLEUKIN 1 BETA,DAN MATRIX METALLOPROTEINASE-16, DENGAN SEPSIS NEONATORUM

Mustarim, Mustarim (2019) HUBUNGAN POLIMORFISME GEN BACTERICIDAL PERMEABILITY INCREASING PROTEIN, CLUSTER OF DIFFERENTIATION 14, INTERLEUKIN 1 BETA,DAN MATRIX METALLOPROTEINASE-16, DENGAN SEPSIS NEONATORUM. Doctoral thesis, Universitas Andalas.

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Abstract

ABSTRACT THE RELATIONSHIP OF BACTERICIDAL PERMEABILITY INCREASING PROTEIN, CLUSTER OF DIFFERENTIATION 14, INTERLEUKIN 1 BETA, DAN MATRIX METALLOPROTEINASE-16 GENE POLYMORPHISM WITH NEONATAL SEPSIS Mustarim Neonatal sepsis is a health problem because it causes serious morbidity and mortality in the neonatal care unit. The susceptibility of neonates results from immaturity of immune system development as well of maternal and enviromental risk factors which can cause infection. The aim of this study is to find out the relationship of BPI gene polymorphism rs 4358188, CD14 rs2569190, IL1β rs1143643 and MMP16 rs2669349 with the incidence of neonatal sepsis. This was an observational studies with cross sectional study design with genomic DNA samples of infants with sepsis and non sepsis which stored according to the standard storage of genetic materials in the Biomedical Laboratory of FK UNAND. This research materials is part of the previous research by Dr. dr. Prambudi. Continued with PCR examination, sequencing and bioinformatics analysis. Only IL1β gene polymorphism rs1143643 C>T was associated with the incidence of neonatal sepsis (p = 0.017) and was statistically significant. While no significant relationship was found between BPI gene polymorphism rs4358188 G>T, CD14 rs2569190 A>G and MMP16 rs2664349 G>A with neonatal sepsis (p = 1,000; 0,472; 1,000). It can be conclude that isIL1β gene polymorphism rs1143643 C>T associated with the incidence of neonatal sepsis, and this result can be used as a biomarker of a population which allowed early diagnostic and spesific management plans of accurate predictions for patient’s prognosis. Keywords Neonatal sepsis, Single nucleotide polymorphism, BPI, CD14, IL1β, MMP16, Polymorphism

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