Hubungan Skor Gleason dengan Kadar Prostate Specific Antigen (PSA) pada Pasien Karsinoma Prostat di RSUP Dr. M. Djamil Padang

Diyanah, Nuraini (2019) Hubungan Skor Gleason dengan Kadar Prostate Specific Antigen (PSA) pada Pasien Karsinoma Prostat di RSUP Dr. M. Djamil Padang. Diploma thesis, Universitas Andalas.

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Abstract

Carcinoma prostate is the second most malignant cancer often found in males around the world. Prostate Specific Antigen (PSA) is a glycoprotein enzyme. The increasing level of PSA serum on carcinoma prostate causes disturbance on the basal epithelial of the prostate gland. Histopathology level on carcinoma prostate is determined by the Gleason score. The purpose of this research is to find the correlation between the Gleason score with the Prostate Specific Antigen (PSA) level in RSUP Dr. M. Djamil Padang. The type of this research is analytical research with cross sectional design on the carcinoma prostate patient. Object acquisition is done by using total sampling technique, with the total of 100 patients. Data is obtained from the medical record at RSUP Dr. M. Djamil Padang between the period of January 2014 to December 2018. Chi-Square test is used to analyze the data. The outcome of this research shows that carcinoma prostate patient is often found in the age range 61 – 70 years old (37%). Most of the Gleason score is poorly differentiated (55%). The highest level of PSA is >20 ng/mL (74%). Bivariate analysis shows the p score = 0.998 (p<0.05), which shows that there are no significant correlation between the Gleason score with PSA on carcinoma prostate patient in RSUP Dr. M. Djamil Padang. This research concludes that there is no significant correlation between the Gleason score with the level of Prostate Specific on carcinoma prostate patient. This can happen because there are other factors that affects the Gleason score. Also carcinoma prostate with Gleason score poorly differentiated no longer have the ability to produce PSA. Keywords : Carcinoma Prostate, Gleason Score, Prostate Specific Antigen Karsinoma prostat adalah keganasan kedua yang sering ditemukan pada laki-laki di dunia. Prostate Specific Antigen (PSA) adalah enzim glikoprotein. Peningkatan kadar serum PSA pada karsinoma prostat terjadi akibat gangguan pada lapisan epitel basal kelenjar prostat.Derajat histopatologi pada karsinoma prostat ditentukan oleh skor Gleason. Penelitian ini bertujuan untuk mengetahui hubungan skor Gleason dengan kadar Prostate Specific Antigen (PSA) di RSUP Dr. M. Djamil Padang. Jenis penelitian ini adalah analitik dengan desain cross sectional pada pasien karsinoma prostat. Pengambilan objek menggunakan teknik total sampling, dengan jumlah sebanyak 100 pasien. Data diperoleh dari rekam medik RSUP Dr. M. Djamil Padang periode Januari 2014 – Desember 2018. Analisis data menggunakan uji Chi-Square. Hasil penelitian menunjukkan pasien karsinoma prostat paling sering terjadi pada kelompok usia 61-70 tahun (37%). Skor Gleason terbanyak adalah poorly differentiated (55%). Kadar PSA terbanyak adalah pada kadar >20 ng/mL (74%). Analisis bivariat menunjukkan nilai p = 0,998 (p<0,05), dimana tidak terdapat hubungan yang bermakna antara skor Gleason dengan kadar Protate Specific Antigen (PSA) pada pasien karsinoma prostat di RSUP Dr. M. Djamil Padang. Penelitian ini menyimpulkan tidak terdapat hubungan yang bermakna antara skor Gleason dengan kadar PSA pada pasien karsinoma prostat. Hal ini dapat disebabkan karena terdapat faktor lain yang mempengaruhi skor Gleason selain kadar PSA. Serta, karsinoma prostat dengan skor Gleason poorly differentiated sudah tidak lagi memiliki kemampuan untuk memproduksi PSA. Kata kunci : Karsinoma Prostat, Skor Gleason, Prostate Specific Antigen

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