Pengaruh Fraksi Etil Asetat Daun Binahong (Anredera cordifolia (Ten.) Steenis)Terhadap Kadar Asam Urat Mencit Jantan Hiperurisemia

Lili, Wahyuni (2018) Pengaruh Fraksi Etil Asetat Daun Binahong (Anredera cordifolia (Ten.) Steenis)Terhadap Kadar Asam Urat Mencit Jantan Hiperurisemia. Diploma thesis, Universitas Andalas.

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Abstract

PENGARUH FRAKSI ETIL ASETAT DAUN BINAHONG (Anredera cordifolia (TEN.) STEENIS) TERHADAP KADAR ASAM URAT MENCIT JANTAN HIPERURISEMIA ABSTRAK Studi tentang pengaruh fraksi etil asetat daun binahong (Anredera cordifolia (Ten.) Steenis) terhadap kadar asam urat mencit jantan hiperurisemia telah dilakukan. Sebanyak 25 mencit jantan terlebih dahulu diinduksi dengan jus hati ayam 25 g/kg secara per oral selama 14 hari untuk mendapatkan hewan uji hiperurisemia. Hewan uji dibagi menjadi enam kelompok yaitu yang menerima 12,5 mg/kg, 25 mg/kg dan 50 mg/kg fraksi, kontrol positif, kontrol negatif dan allopurinol 10 mg/kg sebagai pembanding. Analisis data menggunakan analisis varians (ANOVA) dua arah diikuti uji wilayah berganda Duncan (Duncan’s Multiple Range T-test) dengan interval kepercayan 95%. Penelitian ini menyatakan bahwa fraksi yang digunakan menurunkan kadar asam urat darah. Efek penurunan terbaik dari fraksi ditunjukkan oleh dosis 50 mg/kg. studi ini menunjukkan bahwa fraksi etil asetat dari A. cordifolia menunjukkan aktivitas antihiperurisemia yang berpotensi untuk perkembangan obat di masa depan. Kata kunci: Anredera cordifolia, fraksi etil asetat, hiperurisemia, asam urat THE EFFECT OF ETHYL ACETATE FRACTION OF MADEIRA VINE LEAVES (Anredera cordifolia (TEN.) STEENIS) ON URIC ACID LEVELS OF MALE HYPERURICEMIA MICE ABSTRACT A study on the effect of ethyl acetate fraction of madeira vine leaves (Anredera cordifolia (ten.) steenis) on uric acid levels of male hyperuricemic mice has been carried out. A number of 25 male mice were induced with chicken liver juice 25 g/kg orally for 14 days to obtain hyperuricemic animal. The mice were divided into six groups receiving 12.5 mg/kg, 25 mg/kg and 50 mg/kg of the fraction, positive control, negative control and allopurinol 10 mg/kg as the reference. The data were analyzed with two-way analysis of variance (ANOVA) followed by Duncan’s MRT (95% confidence interval). The study revealed that the fraction decreased blood uric acid levels. The best lowering effect of the fraction was shown by the dose of 50 mg/kg. The study suggests that the ethyl acetate fraction of Anredera cordifolia exhibits antihyperuricemic activity that could be potential for future development of drugs. Keyword: Anredera cordifolia, ethyl acetate fraction, hyperuricemia, uric acid

Item Type: Thesis (Diploma)
Primary Supervisor: Yori Yuliandra, M.Farm, Apt
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Farmasi
Depositing User: s1 Fakultas Farmasi
Date Deposited: 23 Jan 2019 17:15
Last Modified: 09 Nov 2022 02:32
URI: http://scholar.unand.ac.id/id/eprint/42177

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