PEMBERIAN LYOPHILIZED BACTERIAL LYSAT PADA PENYAKIT PARU OBSTRUKTIF KRONIS STABIL YANG MEMILIKI KOLONISASI POTENTIALY PATHOGENIC MICROORGANISM

POVI, PADA INDARTA (2018) PEMBERIAN LYOPHILIZED BACTERIAL LYSAT PADA PENYAKIT PARU OBSTRUKTIF KRONIS STABIL YANG MEMILIKI KOLONISASI POTENTIALY PATHOGENIC MICROORGANISM. Masters thesis, Universitas Andalas.

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Abstract

ABSTRACT Background : Exacerbations in COPD patients influence the severity of the disease. Bacterial colonization in COPD patients is considered to contribute to the incidence of exacerbations. Efforts to reduce bacterial colonization are carried out to reduce the incidence of exacerbations, one of which is vaccination. The purpose of this study was to find out the effect of the administration of Lyophilized bacterial lysat in patients with known type with potentialy pathogenic microorganism in their sputum Method: Open clinical trial in efect of Lyophilized bacterial lysate compare to Plasebo In COPD patient with PPM colony. The study performed in Dr.M.Djamil Hospital Padang from January to June 2017. Subject were taken by accidental sampling. Results: We Administored Lyophilized bacterial lysate on 33 stable COPD with PPM and Plasebo on 22 stable COPD patient with PPM. After treatment for 3 months in the the propotional multy bacterial colony on PPM decrease in Lyophilized bacterial lysate group (10 to 10) p=0.002 Whereas colony was found in single bacteria before (23 to 26). The placebo group did not change either multy bacterial colony. Colony of Klebsiella Pneumonia(-6), Pseudomonas Aureginosa (-2),Stapilococcus Areus (-6) statisticaly significant decrease (p=0,001). Conclusion: Lyophilized bacterial lysate could decreased potential pathogenic microorganism by multy bacterial in patients with stable COPD placebo. Lyophilized bacterial lysat also reduces potential colonies of pathogenic microorganism especially, klebsiella pneumoniae, staphylococcus aureus and pseudomonas aeruginosa. Keywords: COPD, colonization, Lyophilized bacterial lysat

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