PERBEDAAN KADAR ZINC DAN KADAR INTERLEUKIN 6 PADA PERSALINAN PRETERM DAN KEHAMILAN NORMAL

Visti, Delvina (2018) PERBEDAAN KADAR ZINC DAN KADAR INTERLEUKIN 6 PADA PERSALINAN PRETERM DAN KEHAMILAN NORMAL. Masters thesis, Universitas Andalas.

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Abstract

ABSTRAK PERBEDAAN KADAR ZINC DAN KADAR INTERLEUKIN 6 PADA PERSALINAN PRETERM DAN KEHAMILAN NORMAL Visti Delvina Persalinan preterm adalah persalinan yang terjadi antara 20 minggu dan sebelum 37 minggu kehamilan yang ditandai adanya kontraksi teratur dari uterus yang dapat menyebabkan penipisan dan pendataran serviks. Persalinan preterm menyebabkan tingginya angka morbiditas dan mortalitas perinatal. Meningkatnya kadar interleukin 6 dan kurangnya asupan zinc selama kehamilan dapat menstimulasi terjadinya persalinan preterm. Tujuan penelitian ini adalah untuk mengetahui perbedaan kadar zinc dan kadar interleukin 6 pada persalinan preterm dan kehamilan normal. Desain penelitian ini adalah cross sectional komparatif, penelitian dilakukan di RSUD Rasidin, RSI Siti Rahmah dan Laboratorium Biomedik Fakultas Kedokteran Universitas Andalas Padang pada bulan Februari 2017 – Juni 2018. Jumlah sampel sebanyak 50 orang yang dipilih secara consecutive sampling, yang dibagi menjadi dua kelompok yaitu persalinan preterm dan kehamilan normal. Kadar interleukin 6 dan kadar zinc diperiksa dengan metode ELISA. Data dianalisa menggunakan uji t test indepedent. Hasil penelitian rerata kadar zinc pada kelompok persalinan preterm 12,22 ± 0,41 µmol/L dan rerata kadar zinc pada kelompok kehamilan normal adalah 13,96 ± 0,64 µmol/L dengan nilai p 0,000. Rerata kadar IL-6 pada kelompok persalinan preterm adalah 90,22 ± 21,41ng/L dan rerata kadar IL-6 pada kelompok kehamilan normal adalah 75,57 ± 14,01 ng/L dengan nilai p 0,006. Secara statistik terdapat perbedaan yang bermakna antara kadar zinc dan kadar IL-6 pada persalinan preterm dan kehamilan normal. Kesimpulan, kadar zinc pada kelompok persalinan preterm lebih rendah daripada kelompok kehamilan normal dan kadar IL-6 pada kelompok persalinan preterm lebih tinggi daripada kelompok kehamilan normal. Kata Kunci : Kadar zinc, kadar IL-6, persalinan preterm ABSTRACT THE DIFFERENCES BETWEEN ZINC AND INTERLEUKIN 6 LEVELS IN PRETERM LABOR AND NORMAL PREGNANCY Visti Delvina Preterm labor occurs between 20 weeks and before 37 weeks of pregnancy. It is indicated by regular contractions of the uterus and it may cause the thinning and flattening of the cervix. Preterm labor also causes the high rates of perinatal morbidity and mortality. Increasing levels of interleukin 6 and consume less zinc during pregnancy can stimulate the preterm labor. The purpose of this study was to determine differences in zinc levels and interleukin 6 levels in preterm labor and normal pregnancy The design of this reseacrh was a comparative cross sectional study. It was conducted in Rasidin District Hospital, Siti Rahmah Hospital and Biomedical Laboratory, Faculty of Medicine, Andalas University, Padang on February 2017 to June 2018. There were 50 samples in this reseach. It was selected by consecutive sampling. The samples were divided into two groups: preterm labor and normal pregnancy. The interleukin 6 levels and zinc levels were examined by the ELISA method. Then, the data were analyzed by using the t test independent. The results of this reseach showed that the mean level of zinc level in the preterm labor group was 12.22 ± 0.41 μmol / L and 13.96 ± 0.64 μmol / L of the mean zinc level in the normal pregnancy group with p= 0.000. Next, the mean of IL-6 in the preterm labor group was 90.22 ± 21.41ng / L. Then, 75.57 ± 14.01 ng / L for the mean level of IL-6 in the normal pregnancy group with p= 0.006. Moreover, statistical test inffered that there were significant differences between zinc levels and IL-6 levels in preterm labor and normal pregnancy. In short, it can be concluded that zinc levels group in the preterm labor were lower than the normal pregnancy group. Then, IL-6 levels in the preterm labor group were higher than normal pregnancy group. Keywords: zinc levels, IL-6 levels, preterm labor

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