PREVENTIVE EFFECT OF MENTAWAI TARO (Colocasia esculenta; ARACEAE) AGAINST INFLAMMATION AND OXIDATIVE STRESS IN COLON OF MICE FED WITH HIGH-FAT DIET

Adam, Raihan Priambada (2023) PREVENTIVE EFFECT OF MENTAWAI TARO (Colocasia esculenta; ARACEAE) AGAINST INFLAMMATION AND OXIDATIVE STRESS IN COLON OF MICE FED WITH HIGH-FAT DIET. Diploma thesis, Universitas Andalas.

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Abstract

Inflammatory bowel disease is one of the diseases that is closely related to the emergence of colorectal cancer and has twice the potential to develop colorectal cancer. This study aims to reveal the efficacy of mentawai taro tubers (Colocasia esculenta L.) by using various mentawai taro preparations that are thought to prevent intestinal inflammation and increased levels of free radicals in the intestine in the form of malondialdehyde (MDA), as well as revealing bioactive compounds in mentawai taro that can prevent signaling in the mechanism of intestinal inflammation. Conditioning of intestinal inflammation in test animals by giving High fat diet (HFD)and mixing HFD with preparations from Mentawai taro in the form of flour, fiber and starch. The parameters measured in histomorphic parameters are colon diameter, thickness of the tunica mucosal layer, thickness of the tunica muscularis layer, submucosal edema and epithelial integrity, measurement of MDA levels in the colon and in silico molecular docking studies. In this study, it was found that the administration of taro preparations in the form of fiber and starch was able to suppress changes in colon histology in the form of submucosal edema, mentawai taro preparations in the form of flour, starch and fiber were able to suppress MDA accumulation in the colon. Molecular docking results were obtained where Astaxanthin is a bioactive compound of Mentawai taro in inhibiting intestinal signaling with a binding affinity of -9.0 kcal/mol.

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