EFFECT OF MENTAWAI TARO (Colocasia esculenta L., Araceae) CORM ON BLOOD SUGAR AND HISTOPATHOLOGY OF PANCREAS IN ALLOXAN-INDUCED DIABETIC MICE

Wardatul, Aini (2023) EFFECT OF MENTAWAI TARO (Colocasia esculenta L., Araceae) CORM ON BLOOD SUGAR AND HISTOPATHOLOGY OF PANCREAS IN ALLOXAN-INDUCED DIABETIC MICE. Diploma thesis, Universitas Andalas.

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Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia, which is a high level of sugar in the blood for a long time caused by the inability of body cells to metabolize carbohydrates properly. This study aims to reveal the effect of Mentawai taro (Colocasia esculenta L.) corm as a food preparation that can stabilize blood sugar profile and protect pancreatic beta cell damage due to alloxan-induced diabetes mellitus. This study was conducted experimentally from March 2023 to June 2023 using a completely randomized design (CRD) with five treatments and five replicates. Mice were treated with normal feed (RatBio) and normal feed subsumed with Mentawai taro preparations in the form of flour, fiber and starch (25%) for 4 weeks continuously. Furthermore, blood sugar profile, glucose tolerance and insulin were measured and pancreatic histology was observed microscopically. The results showed that the administration of Mentawai taro corm preparations, especially 25% Mentawai taro fiber, was able to lower blood sugar levels to normal conditions, improve tolerance to glucose and insulin and reduce structural damage to the pancreas of alloxan-induced mice. The conclusion of this study is that the administration of 25% fiber of Mentawai taro corm could effectively reduce random blood sugar levels, while the whole flour, fiber and starch of Mentawai taro corm could effectively reduce fasting blood sugar levels and insulin intolerance, and the fiber and whole flour could effectively reduce glucose intolerance in alloxan-induced diabetes mellitus mice. The fiber of Mentawai taro corm could improve the histopathological alterations in the islet of Langerhans including an increase of islet area and total number of islet cells, while the whole flour, fiber and starch could effectively reduce the number of degenerated islet cells.

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