ANTI-INFLAMMATORY EFFECT OF ECO-ENZYMES FROM BANANA AND ORANGE FRUIT PEELS ON CARRAGEENAN-INDUCED MICE

Elni, Fatimah (2023) ANTI-INFLAMMATORY EFFECT OF ECO-ENZYMES FROM BANANA AND ORANGE FRUIT PEELS ON CARRAGEENAN-INDUCED MICE. Diploma thesis, Universitas Andalas.

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Abstract

Inflammation is a positive response of the body against tissue damage or pathogen infection. The use of commercial anti-inflammatory drugs from steroid and non-steroid groups in the long term can cause many side effects. For this reason, it is necessary to develop anti-inflammatory drugs based on natural ingredients that are effective, safe, and affordable. Eco-enzymes have been widely used in various aspects of life. However, scientific information regarding its potential as a medicinal material is still very limited. This study aims to reveal the effect of eco-enzymes from banana and orange peels as anti-inflammatories through experimental analysis of their inhibition of inflammation, hematological response, inflammatory cell count, and collagen score in an animal model of male white mice Balb/c strain. Mice were divided into five different treatment groups namely G1 (mice without induction of inflammation), G2 (induced by carrageenan inflammatory substance 1%), G3 (induced by carrageenan + Betamethasone valerate 0.1%), G4 (induced by carrageenan + banana peel eco-enzyme 200 µl), and G5 (induced carrageenan + orange peel eco-enzyme 200 µl). The results showed that eco-enzymes from banana and orange peels were effective in reducing the thickness of mice’s dorsal skin folds and had anti-inflammatory power of 24.28% in banana peel eco-enzymes and reached 29.04% in orange peel eco-enzymes. The administration of eco-enzymes was able to suppress the quantity of leucocytes, the thickness of the dermis layer, and the number of inflammatory cells and maintain the collagen score in the normal range. Thus, these findings indicate that eco-enzymes from banana and orange peels have the potential to be developed into effective, affordable, and environmentally friendly anti-inflammatory drugs.

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