Effect Of Andaliman (Zanthoxylum acanthopodium DC., Rutaceae) Fruit Ethanol Extract On Diabetic Neuropathy In Alloxan-Induced DM Mice

Arin, Saparima Simatupang (2023) Effect Of Andaliman (Zanthoxylum acanthopodium DC., Rutaceae) Fruit Ethanol Extract On Diabetic Neuropathy In Alloxan-Induced DM Mice. Diploma thesis, Universitas Andalas.

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Abstract

Diabetic neuropathy is a symptom or sign of nerve dysfunction in diabetics due to hyperglycemia over a long period of time, characterized by numbness and burning pain in the feet and hands, especially at night, resulting in decreased quality of life. The use of chemical drugs can have negative effects on the body. Thus, effective utilization of natural compound is needed; one of the potential medicinal compound is andaliman fruit (Z. acanthopodium). Research on the effect of andaliman fruit ethanol extract on diabetic neuropathy in mice with alloxan-induced diabetes mellitus aims to determine the effectiveness of andaliman fruit extract (Z. acanthopodium) in overcoming diabetic neuropathy in mice and at the same time identify bioactive compounds contained in andaliman ethanol extract. This research was conducted from August to September 2022 at the Animal Physiology Research Laboratory. This study uses an experimental method consisting of 5 treatments and 5 replicates, namely a positive control (non-diabetic), diabetes mellitus mice (without administration of extracts), and aliman fruit extract (Z. acanthopodium) at 150, 300, and 450 mg/kg BW. There are bioactive compounds identified as potential antidiabetic neuropathy, namely thiosemicarbazone, oleic acid, eucalyptol, decanoic acid, acetic acid, and arginine. The extract of andaliman fruit effectively relieves loss of sensation in foot function disorders and motor balance disorders due to diabetic neuropathy and can also could ameliorate purkinje cell damage in diabetic neuropathy. However, it could not significantly reduce the accumulation of malondialdehyde (MDA) in the tissue of the central nervous system due to diabetic neuropathy.

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