Pengaruh Pemberian N-Actylcysteine (NAC) terhadap Kadar Malondialdehyde (MDA) pada Penderita Diabetes Melitus Tipe 2

Athifa, Alya Putri (2023) Pengaruh Pemberian N-Actylcysteine (NAC) terhadap Kadar Malondialdehyde (MDA) pada Penderita Diabetes Melitus Tipe 2. Diploma thesis, Universitas Andalas.

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Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Several classifications of diabetes mellitus include type 1 diabetes, type 2 diabetes, gestational diabetes, and other types of diabetes. Type 2 diabetes mellitus is caused by chronic hyperglycemia which causes cell and tissue damage due to increased levels of reactive oxygen species (ROS) which cannot be compensated by antioxidants. To reduce ROS levels, a definitive therapy is needed, namely by administering exogenous antioxidants, one of which is N-Acetylcysteine (NAC) therapy. N-Acetylcysteine works by forming the antioxidant gluthathione which aims to fulfill the body's natural antioxidant deficit in overcoming hyperglycemia. This study was a true experimental research study with a pre-posttest research design. The sample used was 20 patient blood serum samples, which were measured for MDA levels before NAC administration. Then, NAC therapy was administered at a dose of 3X400 mg per day for 5 weeks, and MDA levels were measured after the therapy using the Thiobarbituric Acid Reactive Substance (TBARS) method. The results of the study showed that the mean MDA level before administration of NAC and the average MDA level after administration of NAC respectively, is 3.28 ± 0.427 nmol/ml, and 2.76 ± 0.251 nmol/ml.. There was a significant decrease in MDA levels in the blood serum of type 2 diabetes patients with a value of p = 0.000 (p <0.5). Thus, it can be concluded that the use of NAC has an effect on reducing MDA levels in type 2 diabetes mellitus patients. Keywords: Type 2 diabetes mellitus, Malondialdehyde, NAC.

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