HUBUNGAN EKSPRESI E CADHERINE DENGAN TIPEHISTOPATOLOGIK TUMOR GANAS EPITEL OVARIUM

Hera, Novianti (2016) HUBUNGAN EKSPRESI E CADHERINE DENGAN TIPEHISTOPATOLOGIK TUMOR GANAS EPITEL OVARIUM. Masters thesis, Universitas Andalas.

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Abstract

Latar Belakang Tumor ganas epitel ovarium merupakan keganasan ginekologi kedua terbanyak di dunia dan menjadi penyebab kematian kelima akibat keganasan, bersifat proliferatif intra abdomen dengan invasi dan metatasis yang seringkali mengakibatkan kegagalan terapi. Tumor ganas epitel ovarium diklasifikasikan menjadi tipe I dan II. Tipe II dengan prognosis yang lebih buruk dan lebih banyak bermetastasis. Salah satu protein transmembran yang memiliki peran penting dalam proses metastasis dan invasi tumor adalah E cadherine. Peran E cadherine sebagai faktor penentu prognostik tumor ganas epitel ovarium masih dalam perdebatan. Tujuan Penelitian ini bertujuan untuk melihat hubungan ekspresi E cadherine pada tumor ganas epitel ovarium dengan tipe histopatologik. Metode Sampel pada penelitian ini sebanyak 32 kasus tumor ganas epitel ovarium yang telah didiagnosis di laboratorium Patologi Anatomik di kota Padang. Sampel diperoleh dari blok parafin yang berasal dari hasil operasi. Selanjutnya dilakukan review terhadap tipe histopatologik yang membagi tumor menjadi tipe I dan II.. Ekspresi E cadherine dinilai secara imunohistokimia ditandai dengan warna coklat pada membran sel tumor. Analisis stasistik bivariat menggunakan Chi Square dengan nilai p<0.05 dianggap bermakna. Hasil Ekspresi E cadherine positif ditemukan pada 22 kasus, yaitu pada 12 kasus tumor ganas epitel tipe I dan 10 kasus tumor ganas epitel tipe II, p =0,704 (p> 0,05). Distribusi usia berdasarkan tipe histopatologik pada tumor ganas epitel serosum tipe II didapatkan usia yang lebih tua dibandingkan tipe I, dengan usia rata-rata 51¬+5,56. Usia tidak menunjukkan hubungan bermakna dengan tipe histopatologik tumor ganas epitel ovarium. Tidak terdapat hubungan bermakna antara ekspresi E cadherine dengan tipe histopatologik tumor ganas epitel ovarium. Kesimpulan Ekspresi E cadherine menunjukkan hubungan yang tidak bermakna dengan tipe histopatologik tumor ganas epitel ovarium pada penelitian ini. Kata kunci: tumor ganas epitel ovarium, ekspresi E cadherine, tipe histopatologik. THE ASSOCIATION BETWEEN E CADHERINE EXPRESSION WITH HISTOPATHOLOGICAL TYPE OF OVARIAN EPITHELIAL CANCER Hera Novianti, R.Z.Nizar, Pelsi Sulaini Department of Anatomic Pathologic Andalas Medicine Faculty Dr.M.Djamil Hospital Padang ABSTRACT Background Ovarian Epithelial Cancer (OEC) was the second most frequent gynecologic cancer and the fifth leading cause of death from cancer. This tumor is intra abdominal proliferatif with invasion and metastasis causing failure of treatment. They are divided into type I and II. Type II has worse prognosis and metastasis more often. E cadherine is one of transmembran protein that plays important role in metastasis. The role of E cadherine as prognosis factor in OEC is still controversial. Purpose The purpose of this study is to evaluate the association between E cadherine expression and histopathological type in ovarian epithelial cancer (OEC). Methods 32 cases of OvarianEpithelial Cancer diagnosed in Departement of Pathology Anatomy at Padang were included in the study. Samples obtained from paraffin block of tumor tissue from surgery. These tumors are divided into type I and II, samples were reviewed for the histopathological type. Expression of E cadherineof cells membrane were analyzed using immunohistochemistry assay.Bivariate statistical analysis of Chi Square were used and value p < 0.05 were considered significant. Results Positive E cadherine expression has been found in 22 cases, 12 type I and 10type II, p = 0,704 (p> 0,05). Type II were found in older age, 51+5,56 years, but age was not significantly related to histopathological type. There was not significant correlation between E cadherineexpression with histopathological type in ovarian epithelial cancer. Conclusion This study showedthere was not significant association between E cadherineexpression with histopathological type in ovarian serous carcinoma. Keyword: ovarian epithelial cancer, E cadherine expression, histopathological type

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