PENGARUH PEMBERIAN ASPARTAM TERHADAP KADAR LOW-DENSITY LIPOPROTEIN DAN HIGH-DENSITY LIPOPROTEIN PADA TIKUS WISTAR DIABETES MELITUS DIINDUKSI ALOKSAN

REVIVO, RINDA PRATAMA (2014) PENGARUH PEMBERIAN ASPARTAM TERHADAP KADAR LOW-DENSITY LIPOPROTEIN DAN HIGH-DENSITY LIPOPROTEIN PADA TIKUS WISTAR DIABETES MELITUS DIINDUKSI ALOKSAN. Diploma thesis, Universitas Andalas.

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Abstract

Aspartame is an artificial sweetener that has 180-200 times the sweetness of sucrose and has been approved by the FDA for consumption. Consumption of artificial sweeteners is using ADI (Acceptable Daily Intake) dose which is 50 mg/kg. Individuals with diabetes mellitus would likely be enthusiastic consumers of aspartame. Aspartame can influence the metabolism of lipid profile. Various studies on aspartame showed differences in influence the lipid profiles. The purpose of this study was to determine the effect of aspartame on levels of LDL and HDL at rats with diabetes mellitus induced by alloxan. The research is experimental research with randomized post test only control group design. The subjects were 15 male Wistar rats those were divided into three groups: a negative control group (K-), a positive control group (K+) and the treated group (P). Each group consists of five (5) male rats. Administration of aspartame (dose of 315 mg / kg rat) was administered to the treatment group for four (4) weeks. The results showed that administration of aspartame in rats with diabetes mellitus induced by alloxan was influenced the decreased in LDL levels and increased in HDL levels. The LDL levels in positive control group was 30 ± 2 mg/dl, in the treatment group was 24 ± 2 mg/dl. While the levels of HDL in positive control group was 19 ± 1 mg/dl, in the treatment group was 22 ± 1 mg/dl. There is a significant difference in the levels of LDL and HDL between the positive control group with the treatment group. The conclusion of this research are the administration of aspartame in rats with diabetes mellitus induced by alloxan influenced the decreased in LDL levels and increased in HDL levels. Keywords: aspartame, diabetes mellitus, LDL, HDL

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