PERBANDINGAN PROGNOSIS SUBTIPE MOLEKULER KANKER PAYUDARA ANTARA PASIEN KANKER PAYUDARA WANITA USIA MUDA DAN TUA DI RSUP DR. M. DJAMIL PADANG

Irwan, Irwan (2015) PERBANDINGAN PROGNOSIS SUBTIPE MOLEKULER KANKER PAYUDARA ANTARA PASIEN KANKER PAYUDARA WANITA USIA MUDA DAN TUA DI RSUP DR. M. DJAMIL PADANG. Masters thesis, Universitas Andalas.

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Abstract

Introduction : Breast cancer is a heterogenic illness with various biologic profile and clinical prognosis. A research in Netherland by Esther, et al 2013, showed that molecular subtypes of breast cancer have different distribution and prognostic effect between the young and adult, whereas it cannot found in the local and national data. Method : Comparative research with cross sectional design. Held in January-April 2015 with 96 samples of breast cancer women with age ≤ 40 years old and > 40 years old that has been recorded in medical records and breast cancer registration from year 2012-2014. Result : Breast cancer that happened to young women at General Hospital dr. M. Djamil Padang for 3 years (2012-2014) are 27,1% and the adult are 72,9%. In bivariat analysis, there are not relationship between characteristics of tumor with recurrent and death event while in the adult women breast cancer, tumor size and metastases have relation with recurrent and death event that are significant statistically. Conclusion : There are different characteristics and description of breast cancer molecular subtype between young and adult women, young ages are tend to have relative big tumor, lymph node positive, lymphovascular invasion, high grade tumor, proliferation index Ki67 high and negative hormone receptor. There are differences tendency of prognosis women breast cancer between the young and adult based on molecular subtype but statistically, the relationship is not significant. Keyword: age, breast cancer molecular subtype, prognosis

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