PERBEDAAN RERATA KADAR ANGIOPOETIN 2 ANTARA PREEKLAMSI DENGAN HAMIL NORMAL

MIFTAHUL, JANNAH (2016) PERBEDAAN RERATA KADAR ANGIOPOETIN 2 ANTARA PREEKLAMSI DENGAN HAMIL NORMAL. Masters thesis, UNIVERSITAS ANDALAS.

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Abstract

Preeklamsi (PE) merupakan penyebab utama kematian ibu. Penyebab preeklamsi berawal dari gangguan plasenta yang dipengaruhi oleh faktor pro-angiogenik dan anti-angiogenik Salah satu faktor antiangiogenik adalah Angiopoetin 2. Angiopoetin 2 merupakan bagian dari keluarga faktor pertumbuhan. Tujuan penelitian untuk membuktikan perbedaan rerata kadar angiopoetin 2 antara preeklamsi dengan hamil normal. Penelitian dilakukan secara observasional dengan desain cross sectional terhadap 30 ibu preeklamsi dan 30 ibu hamil normal. Pengambilan sampel menggunakan teknik consecutive sampling dengan metode ELISA. Uji normalitas data dengan Shapiro Wilk, uji t tidak berpasangan untuk beda rerata. Hasil penelitian menunjukkan rerata kadar serum Angiopoetin 2 pada kelompok preeklamsi adalah 6,16±3,091 ng/ml dan 4,108±3,087 ng/ml pada hamil normal. Terdapat perbedaan yang bermakna kadar serum angiopoetin 2 antara preeklamsi dengan hamil normal dengan nilai p = 0,013. Kesimpulan penelitian ini adalah terdapat perbedaan yang signifikan kadar serum Angiopoetin 2 antara preeklamsi dengan hamil normal. Kata Kunci : Angiopoetin 2, Preeklamsi, Hamil Normal ABSTRACT THE MEAN DIFFERENCE OF ANGIOPOIETIN 2 LEVELS WITH PREECLAMPSIA AND NORMAL PREGNANCY Miftahul Jannah Preeclampsia (PE) is a major cause of maternal mortality. The cause of preeclampsia originated from the placenta that was influenced by pro-angiogenic and anti-angiogenic. One of angiogenic factors is Angiopoetin 2. Angiopoetin 2 is part of a family of growth factors. The objective of the research to prove the mean difference angiopoetin 2 levels in pregnant women between preeclampsia and normal preganancy. The study design was observational with cross-sectional study on 30 preeclampsia and 30 pregnant women. The sample is based on consecutive sampling by ELISA method. Normality test data by Shapiro Wilk, Independent t test for mean difference. Results showed the mean serum levels Angiopoetin 2 in the preeclampsia group was 6,16 ± 3,091 ng/ml and 4,108 ± 3,087 ng/ml in normal pregnancy. There is difference angiopoetin 2 levels between preeclampsia and normal preganancy with p = 0,013. It is concluded that there is significant differences between the angiopoetin 2 levels in pregnant women with preeclampsia and normal pregnancy. Keywords : Angiopoetin 2, Preeclampsia, Normal Pregnancy

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