PERBEDAAN RESPON KRIOTERAPI PADA PASIEN DENGAN NEOPLASIA INTRAEPITELIAL SERVIKS DERAJAT RENDAH DAN TINGGI BERDASARKAN DNA HPV

Elvita, Asril (2016) PERBEDAAN RESPON KRIOTERAPI PADA PASIEN DENGAN NEOPLASIA INTRAEPITELIAL SERVIKS DERAJAT RENDAH DAN TINGGI BERDASARKAN DNA HPV. Masters thesis, UNIVERSITAS ANDALAS.

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Abstract

Objective: To assess the effectiveness of cryotherapy in cervical intraepithelial neoplasia based on severity using HPV DNA Methods: This research was by analytic observational study with cross sectional approach with posttest control group design in the department of oncology gynecologic clinic of Dr. M. Djamil, Padang since September 2015 - June 2016. Obtained samples are 32 people who are grouped into two groups: low and high grade cervical intraepithelial neoplasia (CIN), each group had samples of 16 people who met the inclusion criteria and no exclusion criteria. All patients were administered according to the standard procedure and treated by cryotherapy and HPV DNA examination. In the first group performed HPV DNA testing before and after the action of cryotherapy, while in the second group of HPV DNA testing done after cryotherapy. HPV DNA testing after cryotherapy done within 3-6 months thereafter. Results: The results indicate that HPV DNA negative in all samples in both groups after cryotherapy. Conclusion: Cryotherapy has an effect in the clearance of HPV virus in patients with high-grade dysplasia. Keywords: cryotherapy, cervical intraepithelial neoplasia, human papillomavirus DNA.

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